Poor scientific acumen. Perhaps because of this, the focus has shifted from innovation toward services and short-term results.
A few problematic managers are disrespectful, disregard input, rely on high-pressure tactics, and engage in projection and gaslighting to deflect from their own insecurities and limited scientific and interpersonal skills. Despite the unsurprisingly high turnover, HR and upper management seem either unaware of the issue or unwilling to address it, which ends up normalising poor behaviour and demoralising the team.
There would likely be even higher turnover if the biotech job market were more favourable.