too many to list. the environment is toxic, managers are not able to guide the research and to have constructive discussions with Scientist. Quality of science sometimes is questionable is rather quick and dirty than proper and thorough. there is no salary growth for scientists even though they do all the work. they supervise students, write grants, do the science, write papers and get a third/fourth of the salary of PIs and managers. the institute puts a lot of energy in looking good, with social media, news, public events, but then is unable the deliver high impact science. this is proven by the fact that there have been almost no publications in top journals e.g. nature science cell in the last decade.